You and I are not meaningless. The universe is not simply a flexing something that came from and will return to nothing. There is God, and His being gives meaning. There is, however, no shortage of vocal deniers of God’s existence. Faith in a revealed and speaking God is increasingly under attack, and even those who do not actively disbelieve often find the entire question of God irrelevant.
This state of affairs is not new. In Romans 1, Paul begins to explain the human condition that causes men to “hold down the truth in unrighteousness” (v. 18). This is not simply telling a lie, or not acknowledging a true thing, but holding down the truth.